Pharmacological Profiles of Several Common Drugs

Pharmacological Profiles of Several Common Drugs 2.3 Profile of Pheniramine Maleate (31) Chemical name: (3RS)-N,N-Dimethyl-3-phenyl-3-(pyridine-2-yl)propan-1-amine(Z)-butenedioate Empirical formula: C20H24N2O4 Chemical structure: Figure 2.3:Structure of Pheniramine Maleate 2.3.1 Physical properties Molecular weight: 356.4 Appearance and colour: White or almost white crystalline powder. Solubility: Very soluble in water, freely soluble in ethanol (96 %)in methanol and in methylene chloride. Therapeutic category:Pheniramine maleate belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, Decongestant. Dosage: Tablet , Powder, Solution 2.3.2 Pharmacology Pheniramine maleate is an antihistamine used for alleviation of allergy symptoms. Manufacturers frequently list the over-the-counter medication as pheniramine maleate or a derivative. Drug industries also often combine the formulation with other medications for relief of other symptoms. Consumers can generally find the ingredient in an oral solution or tablet form. Certain ophthalmic solutions also contain pheniramine maleate, which provides relief from allergy symptoms associated with the eyes. Allergic reactions are autoimmune responses to certain antigens. When allergens enter the bloodstream, the body releases histamine, which binds with and activates receptor sites, located throughout the body, producing physical symptoms. The pharmacological action of pheniramine maleate involves blocking the receptor sites for the histamine H1, found in the heart, central nervous system, smooth muscle, and vascular endothelium cells. Blocking the receptor sites reduces or inhibits the symptoms. The antihistamine is frequently used for seasonal allergies, such as hay fever, or environmental allergies, such as animal dander. By blocking histamine receptor sites, pheniramine maleate can reduce or eliminate itching, watery eyes, runny noses, and skin irritations. Allergy related skin irritations might include the itching, redness, and swelling associated with eczema or uticaria, commonly referred to as hives (40). The medication may produce a sedative effect when binding to sites in the central nervous system. It also may produce an anticholinergic effect by dilating or relaxing smooth muscle. These side effects sometimes allow pheniramine maleate to be used as treatment for motion sickness or the inner ear condition known as Meniere’s disease. 2.4 Profile of Phenylephrine Hydrochloride (78) Chemical name:(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride Empirical formula:C9H13NO2HCL Chemical structure: Figure 2.4 : Structure of Phenylephrine Hydrochloride 2.4.1 Physical properties Molecular weight:203.67 Appearance and colour: White or practically white odourless crystals Solubility: Freely soluble in water and alcohol Therapeutic category: Phenylephrine is a sympathomimetic amine that acts predominantly on ÃŽ ±-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs. Dosage: Cream, Solution, Ointment, Injection, Liquid, Tablet, Suppository 2.4.2 Pharmacology In general, ÃŽ ±1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. ÃŽ ±1-receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three ÃŽ ±1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: ÃŽ ±1A (chromosome 8), ÃŽ ±1B (chromosome 5), and ÃŽ ±1D (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The ÃŽ ±1A-receptor maintains basal vascular tone while the ÃŽ ±1B-receptor mediates the vasocontrictory effects of exogenous ÃŽ ±1-agonists. Activation of the ÃŽ ±1-receptor activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on ÃŽ ±1-adrenergic receptors peripheral vascular smooth muscle. Stimulation of the ÃŽ ±1-adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on ÃŽ ±1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities. 2.5 Profile of Dextromethorphan (79) Chemical name:(1R,9R,10R) 4 methoxy 17 methyl – 17 azatetracyclo[7.5.3.0{1,10}.0{2,7}]heptadeca-2,4,6-triene Empirical formula:C18H25NO Chemical structure: Figure 2.5 : Structure of Dextromethorphan 2.5.1 Physical properties Molecular weight:271.39 Appearance and colour: It is a White crystalline powder Solubility: 1-5 g/100 mL at 21 Â ºC Therapeutic category: Dextromethorphan usually used in the treatment of respiratory infections and allergic conditions Dosage: Tablet , Syrup, Capsule, Suspension 2.5.2 Pharmacology Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. 2.6 Profile of Diphenhydramine (80) Chemical name: 2-(diphenylmethoxy)-N,N-dimethylethanamine Empirical formula:C17H21NO HCL Chemical structure: Figure 2.6 : Structure of Diphenhydramine 2.6.1 Physical properties Molecular weight:291.82 Appearance and colour: It is a White crystalline powder Solubility: Soluble in DMSO, acetone, water Therapeutic category: Diphenhydramineis a first-generationantihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms. The drug has a strong hypnotic effect and is FDA-approved as a non-prescription sleep aid, especially in the form of diphenhydramine citrate Dosage: Capsule 2.6.2 Pharmacology Diphenhydramine is an inverse agonist of the histamineH1receptor. It is a member of the ethanolamine class of antihistaminergic agents. By blocking the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier (BBB) and antagonizes the H1 receptors centrally. Its effects on central H1 receptors cause drowsiness. Like many other first-generation antihistamines, diphenhydramine is also a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors), and, as such, at high doses can cause anticholinergic syndrome. The utility of diphenhydramine as

The Massachusetts Technology Sector Essay -- Journalism Journalistic E

The Massachusetts Technology Sector After working for more than five years as a software engineer at a Massachusetts-based digital-video editing company, Dave Lanzar decided it was time to take a chance and join the ranks of a start-up streaming media company that had yet to go public. â€Å"The future was rosy and we were all going to get rich,† Lanzar said. But that future never materialized, and the company that was supposed to make Lanzar rich no longer exists. He was laid off in August 2001, one month before the terrorist attacks on Sept.11, 2001 accelerated an already progressing downturn in the job market that hit the Massachusetts technology sector especially hard. Lanzar did not work as a programmer again for over two years. During that time he burnt through his entire savings and starting doing odd jobs like baby-sitting and lawn-work to survive. In October 2003 he secured a several-month-long contract job. After the contract ended in early 2004, it was six more months until Lanzar found a permanent job. Even though he is back to work, his extended, unpaid and unwanted vacation still haunts him. â€Å"I definitely, sometimes feel my rustiness. I’m having to work very hard to overcome that,† Lanzar said. The Massachusetts high-tech industry has been the setting for thousands of similar stories since 2001. The Greater Boston Chamber of Commerce reported that, between 2001 and 2003, the Boston area alone lost 32,000 high-technology jobs -- a 22 percent loss. The Mass Software Council reported in the 2004-2005 edition of its yearly software industry research publication, The Complete Guide to the Massachusetts Software Industry, that the state lost 121 software companies and 3,859 software-related jobs in 2... ...the state will not invest too heavily in one specific technological growth area, such as stem-cell research, while ignoring the rest. â€Å"We think if there’s going to be an investment in technology, it should be more broad-based,† said Boulanger. Boulanger also warns of possible dangers looming on the horizon that could impede growth. He points to proposed Massachusetts House bill 2606 as a potential momentum killer. The bill aims to close corporate tax loopholes, and includes a measure to ensure that any software bought online would be subject to state tax. The bill claims this loophole is worth an estimated $50 million dollars in yearly revenue. â€Å"It’s definitely moving in the wrong direction,† Boulanger said. â€Å"The state government has the ability to make Massachusetts companies more competitive around the margins. And that is all we are really asking for.†

Globalization: International Trade and World Trade Organization Essay

1.Describe how the world economy is becoming more integrated than ever before. The global economy is becoming more integrated than ever before. The world trade organization (WTO), now has 153 countries involved in more than 95 percent of the world’s trade. The global economy is dominated by countries in three regions: Western Europe, North America, and Asia. Europe is economically to form he biggest market in the world. Under the Maastricht Treaty, which formally established the European Union (EU), the euro was adopted as a common currency among European countries with the goal to strengthen Europe’s position as an economic superpower in the world. Among the Pacific Rim countries, Japan dominated world attention toward the end of the last century and with the world’s largest population and increasing industrialization, China is on its way to becoming the larges producer and consumer of the world’s goods. Asian countries have joined the United States, Australia, and Russia to form the Asia-Pacific Economic Cooperation (APEC) trade Group. Association of Southeast Asian Nations (ASEAN) brings together 10 developing nations and is aimed at cultural development and political security. The North American Trade Agreement (NAFTA) combined the economies of the United States, Canada and Mexico into one of the world’s largest trading bloc. And, as for the rest of the world with all the important developments, markets and competitors shaping the global environment, India for example with the fast growing economy and huge population has become the world’s second largest online support, software developer and other services. 2.Discuss what integration of the world economy means for individual companies and their managers. Compared with only a few years ago opportunities are greater because the movement toward free trade has opened up many formerly protected national markets. The potential for export and for making direct investment overseas is greater today than ever before. The environment is more complex because today’s manager often has to deal with the challenges of doing business in countries with radically different cultures and coordinating globally dispersed opportunities. The environment is more competitive because in addition to domestic competitors the managers must deal with cost efficient overseas competitors. Companies both large and small now view the world rather than a single country as their market and need to identify the best strategy for competing in a global marketplace. Universal needs exist when the tastes and preferences of consumers in different counties with regard to a product are similar, creating strong pressure for a global strategy. Thus, managers need to make sure that their companies are able to adapt to different needs in different locations not just locally but globally. Irene B. Rosenfeld, the CEO of Kraft and General Foods, understood the importance of globalization and to save the struggling company, aside from its North American market, she also focused on the overseas market. Krafts global expansion strategy targets 10 markets. Also, Kraft will focus on its overseas efforts and research and development for ten best selling brands which accounts for about 40% of Kraft’s international sales and over 60% of its profits.

Earth Day Essay

The subject of Earth Day has been covered intensively by the world press over the past decade. Many an afternoon has been enjoyed by a family, bonding over the discussion of Earth Day. Until recently considered taboo amongst polite society, it is yet to receive proper recognition for laying the foundations of democracy. Often it is seen as both a help and a hinderence to global commercial enterprises, who are yet to grow accustomed to its disombobulating nature. Complex though it is I shall now attempt to provide an exaustive report on Earth Day and its numerous ‘industries’. Social Factors There is cultural and institutional interdependence between members of any community. When Thucictholous said ‘people only know one thing’ [1] he saw clearly into the human heart. Difference among people, race, culture and society is essential on the survival of our world, however Earth Day raises the question ‘why?’ Recent thought on Earth Day has been a real eye-opener for society from young to old. It grows stonger every day. Economic Factors There has been a great deal of discussion in the world of economics, centred on the value of Earth Day. We shall examine the Fish-Out-Of-Water model. Taking special care to highlight the role of Earth Day within the vast framework which this provides. Oil Prices Earth Day What a splendid graph. Obviously oil prices sings a very different tune. Perhaps to coin a phrase Earth Dayeconomics will be the buzz word of the  century Political Factors No man is an island, but what of politics? Comparing the general view of politics held by the poor of the west with those of the east can be like comparing. Consider this, spoken at the tender age of 14 by jazz singer Bonaventure H. Amster ‘Taking a walk across hot coals will inevitably hurt your feet.’ [2] This quotation leads me to suspect that he was not unaccustomed to Earth Day. It speaks volumes. History tells us that Earth Day will always be a vote winner, whether we like it, or not. Why did Earth Day cross the road? – To get to the other side! Just my little joke, but lets hope that Earth Day doesn’t inspire similar hilarity in the next elections. Conclusion To conclude, Earth Day parades along man’s streets and man waves back. It fills a hole, invades where necessary and always chips in.

Prose Criticism of Chuck Palahniuk Invisible Monsters Essay Example

Prose Criticism of Chuck Palahniuk Invisible Monsters Essay Example Prose Criticism of Chuck Palahniuk Invisible Monsters Essay Prose Criticism of Chuck Palahniuk Invisible Monsters Essay Essay Topic: Fight Club Novel Invisible Man Invisible Monsters The purpose of the first few paragraphs of any novel is to set the basic scene, to introduce main characters, and most importantly to make the reader carry on reading! If one starts reading a book and is not gripped by some aspect of the story or characters within the first few pages, many will abandon it in favour of something more engaging. The opening of Invisible Monsters does all of these things and more. It is narrated by one of the main characters, and another two are introduced within the first few paragraphs. Here the narrator tells you quite openly, this is called scene setting: where everybody is, whos alive, whos dead. This sentence in itself prompts one to read on, if only to find out who is dead. In fact, the first paragraph asks a whole hoard of questions in the readers head: who is alive and dead? Who is Evie Cottrell? Who is the narrator? What happened to the rest of Evies wedding dress, and why is she holding a rifle? The style of Invisible Monsters is not that of your every day novel. The story does not run in one straight chronological line, from beginning to end. In fact it is very jumbles and frequently jumps back and forth between past and present. So with the opening of the novel one is left wondering not only what happens next but also what happened before this, how did we get here? This technique is part of what keeps the reader turning the pages not only for the next part of the story but also the last part. Palahniuks style is unique in that, with only a small amount of words he can evoke a whole scene. In the first paragraph there are few adjectives. The wedding reception is big and in a big manor house. The staircase is also big. However, by the use of the language here the reader is able to grasp not only what the scene looks like but also some detail about the narrator and her somewhat limited vocabulary. The whole book is written in the style of a person telling the story verbally rather than writing it down, and the syntax and detail (including that which is omitted) are indicative of this. The piece is a collection of deconstructionist, self-referential stream-of-consciousness asides which affirm the idea of a person telling a story, adding detail as it occurs to them. This bits and pieces exposition builds tension and confusion throughout the book, but especially at the beginning, where information is slowly leaked to the reader. There us a symbiotic relationship between the frenetic style and the wildly unbalanced characters, which fit together perfectly. This allows Palahniuk to breathe more life into his characters than if he had rendered them in a more conventional way. The first character to be mentioned is Evie Cottrell; the scene is set at her wedding reception, and we meet her standing on a staircase, naked inside whats left of her wedding dress, still holding her rifle. The narrator does not seem at all sympathetic to Evie in her description, and in fact there is a certain amount of distaste in the way, further down the page, we are told, You can trace everything about Evie Cottrells look back to some television commercial for an organic shampoo suggesting that Evie is defined more by looks and her outer image than intelligence. The structure of this novel is very fragmented. Paragraphs are short and choppy in some cases only a few words and the non-linear narrative again enforces the superficiality of the characters. The writing is quite plain in its wording and there is little imagistic language (though Brandy is said to be gushing her insides out). The vocabulary is colloquial and varies sometimes using a few simple (some big West Hills wedding reception) and sometimes opting for more descriptive, intelligent words (give me rampant intellectualism as a coping mechanism). The repetition of the word big in the first paragraph is quite telling of the character of the narrator: there are many words that could be used to describe a wedding reception in the West Hills (beautiful, extravagant, luxurious) but all she seems or chooses to note is that it is, simply, big. The lack of descriptive detail here, when later on almost an entire paragraph is devoted to the cut and style of Brandy Alexanders suit is a lso very telling of the characters. The fact Brandy is bleeding g from a bullet wound is mentioned almost as an aside the hole in the suit has caused the single-breasted cut to become asymmetrical. This is where Palahniuk is very clever. He does not come out and say that his characters are vacuous and superficial as such, but the narrators choice of words and actions show us. For example, as Brandy Alexander is laying bleeding to death at our feet, our narrator remarks, my first instinct is maybe its not too late to dab club soda on the blood stain. Earlier in the piece, the narrator has also remarked that Shotgunning anybody in this room would be the moral equivalent of killing a car. Were all such products. A very existential comment in which she places herself in the same category as her two worst enemies and is aware that in a sense she is no better than them. Palahniuk has an interesting and quite original way of conveying his characters feelings. He never seems to write, I feel or she felt and so instead expresses the feelings of his characters in quite abstract ways. So where in Fight Club the narrator exclaimed, I am Joes Enraged, Inflamed sense of Rejection, in Invisible Monsters feelings are conveyed in keeping with the brainless images of the characters as calls from a photographer to his model: Give me malice. This is effective not only in that it allows the reader to see how the narrator feels without resorting to I feel (Which would be rather out of character for these people, but it also likens the whole scene to a photo shoot, making it seem that everyone is acting a part which, of course, they are. It begins the idea that all of these characters are fake and perhaps not what they seem, but rather hiding behind the models faà ¯Ã‚ ¿Ã‚ ½ade of Give me In conclusion, this novel opening is very effective. It introduces the characters and scene is such a way that leaves the reader with numerous questions regarding not only the outcome of the present situation, but also how the situation came about. Who are these people? Why is the house on fire? Why is Evie half burned out of her dress and half way down the stairs with a rifle in her hand? Why did she shoot Brandy? And why is the narrator calmly thinking of dabbing club soda on the bloodstains? It certainly makes the reader want to turn the page to find out just what is going on in this rather twisted world we are being drawn into.

Eugenics Essay Example | Topics and Well Written Essays - 1250 words - 1

Eugenics - Essay Example As quoted in "Regulating Eugenics," Francis Galton—who was actually a cousin of Charles Darwin—first used the term "eugenics" in 1883. Galton described it as: But who is to say which "race" or "strain of blood" is more "suitable" than another? This paper will look at several topics concerning eugenics and what the practice might mean in the present day and future. There is a type of eugenics that is practiced in nature. If a zebra is born with a genetic defect that affects its legs, it will very soon be culled from the herd by predators. It is a fact of nature that the weakest and sickest are, in general, the first to die; it is survival of the fittest. Humans are one predator that flip this equation on its ear. How many hunters hope to bag the smallest, sickliest of deer? No, human hunters tend to go for the "prize," thus removing from the gene pool an animal that has some sort of genetic disposition—a better immune system; greater intelligence to protect it from predators, automobiles, or starvation; stronger bones and muscle and greater strength—that has allowed it to reach an enviable size and age. To protect from overpopulation, at least in deer, hunting is a necessity; however, by culling these "trophies" from the population, hunters are weakening the stock that otherwise would have been strengthened by natural selection. But perhaps humans make up for this toying with the nature of things by taking care of our own. In Greek literature, there is mention of blind prophet. Left on his own, this man would likely die; instead, he is cared for and tended by his peers. Whether or not this person is fictional or historical does not matter, for if this behavior exists in literature, it can be reasoned that it existed in real life as well. Throughout literature and history, there is mention of a person disabled

Bring Tare To Justice Case Study Example | Topics and Well Written Essays - 2000 words

Bring Tare To Justice - Case Study Example In October 2007, a winner of the Nobel Prize for Literature donated her money for a campaign that holds Boney Tare accountable for the Anglo-Mesopotistani War in the criminal and civil courts of England. The Lobby started a campaign with the slogan, 'Bring Tare to Justice'. The lobby has approached for advice on the advantages and disadvantages of suing Boney Tare in Civil Courts for Torts of Trespass against Tare in person and against Misfeasance in Public Office. There are thus two ways that justice could be brought against Tare - that is, against Tare as a person and against Misfeasance in Public Office. The potential claimants at the Lobby who can help sue Tare are Omar, who has been interned by the British Army for the last four years in its Detention Facility in Mespotistan, Ali, who was the victim of torture by two British soldiers who were subsequently court-martialled for their acts. Doris, a UK citizen who has never been to Mespotistan, but who is strongly of the opinion Tare should pay exemplary damages to those he has trespassed against. Fatima, whose husband died in the March 2003 bombing raids. Considering an answer to these questions would be the best method to understand the ways in which any legal proceedings could be brought against Boney Tare both on the basis that he has wronged in person and that there has also been Misfeasance in Public Office. After considering the four potential claimants who can help sue and testify against, it can also be decided as to who would be better suited to testify against Tare. For law dealing with the Trespass against the Person, the first issue is whether the English Courts have jurisdiction over a decision taken in England to commit false imprisonments in Mespotistan. Boney Tare can be sued on the basis of Tort or for committing legal wrong of Trespass and Misfeasance. Tort is a branch of Civil law and although similar to criminal law Tort is a case between private parties so in this case, under Tort a case can be brought up against Tare as an individual and Omar who was at the detention facility in Mespotistan or Ali who was a victim of Torture could bring up the case against Tare. The court might order to pay damages to Ali or Omar or stop the wrongful activity (in this case, the invasion and war in Mespotistan). The bilateral aspect of Tort law allows victims to sue the injurers directly without blaming the state and this provision can allow